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Dominic Magirr

Medical Statistician

Novartis

Biography

I'm a medical statistician interested in the design, analysis and interpretation of clinical trials.

Specific research interests include:

  • group sequential trials
  • multiple hypothesis testing
  • adaptive designs
  • survival analysis

Since February 2020 I have been working in the Statistical Methodology Group at Novartis in Basel.

Recent Posts

Landmark/Milestone analysis under a Royston-Parmar flexible parametric survival model using the R package flexsurv

The aim of this post is to demonstrate a landmark/milestone analysis of RCT time-to-event data with a Royston-Parmar flexible …

That'll do: simulated annealing instead of maths

This is a post for future me. Given my steadily declining maths skills, I can see myself needing to use the generalized simulated …

Adjusting for covariates under non-proportional hazards

I’ve written a lot recently about non-proportional hazards in immuno-oncology. One aspect that I have unfortunately overlooked is …

A Bayesian approach to non-proportional hazards

In this blogpost I wanted to explore a Bayesian approach to non-proportional hazards. Take this data set as an example (the data is …

Recent & Upcoming Talks

Generalizing boundaries for triangular designs, and efficacy estimation at extended follow-ups

In this talk I delved into some of the history of John Whitehead's Triangular Test. The context was a mulit-arm trial of several …

Group-sequential and adaptive designs in immuno-oncology

Here I talk about designing a clinical trial for an immuno-oncology endpoint where we expect a delay in the seperation of the survival …

Small trials, historical data. Methods and software for decision making.

Quite often, single-arm studies in early-phase oncology are criticized because they lead to false positives. Here, I wanted to point …