Dominic Magirr

Medical Statistician



I’m a medical statistician interested in the design, analysis and interpretation of clinical trials.

Specific research interests include:

  • group sequential trials
  • multiple hypothesis testing
  • adaptive designs
  • survival analysis

Since February 2020 I have been working in the Statistical Methodology Group at Novartis in Basel.

Recent Posts

Trouble with tau

This post is to express some minor frustration with some papers I’ve read recently evaluating the performance of restricted mean …

A stratified log-rank test does not control alpha for a marginal null hypothesis and that's ok

Recently, I’ve become interested in the robustness of standard statistical methods for RCTs under model misspecification. It seems to …

Multiple imputation without a specialist R package

If you’re interested in doing multiple imputation in R, it’s best to use a specialist package. There are many good options out there, …

Landmark/Milestone analysis under a Royston-Parmar flexible parametric survival model using the R package flexsurv

The aim of this post is to demonstrate a landmark/milestone analysis of RCT time-to-event data with a Royston-Parmar flexible …

That'll do: simulated annealing instead of maths

This is a post for future me. Given my steadily declining maths skills, I can see myself needing to use the generalized simulated …

Recent & Upcoming Talks

Generalizing boundaries for triangular designs, and efficacy estimation at extended follow-ups

In this talk I delved into some of the history of John Whitehead’s Triangular Test. The context was a mulit-arm trial of several …

Group-sequential and adaptive designs in immuno-oncology

Here I talk about designing a clinical trial for an immuno-oncology endpoint where we expect a delay in the seperation of the survival …

Small trials, historical data. Methods and software for decision making.

Quite often, single-arm studies in early-phase oncology are criticized because they lead to false positives. Here, I wanted to point …